Peer reviews & research outputs
All papers published as a result of the work done in the Trials@Home can be found on this page.
When posters or layman articles of papers are available, they have been added below, other posters can be found here.
Some papers also have a short summary video, you can find these here.
Do people prefer to take part in a clinical trial from home or come to site? A discrete choice experiment in type 2 diabetes mellitus
First published: 4 November 2025
Authors: Julia Kopanz, Bart Lagerwaard, Jorien Veldwijk, Julian K Mader, Dietrich Tews, Thomas T van Sloten, Diederick E Grobbee, Mira G P Zuidgeest on behalf of the Trials@Home consortium
The RADIAL paper series at a glance
One pdf with links to all the articles in the series.
Regulatory Interactions and Learnings—RADIAL the Trials@Home Proof-of-Concept Trial on Decentralization
First published: 3 October 2025
Authors: Helga Gardarsdottir, Hamidou Traore, Kate Huntley, Dinesh Mistry, Amos J. de Jong, Agnes Legathe, Tim de Smedt, Scott Askin, Megan Heath, Solange Corriol-Rohou, Bart Lagerwaard, Mira G.P. Zuidgeest, on behalf of the IMI Trials@Home Consortium
Selecting and Preparing Clinical Sites for the Successful Conduct of Decentralized Clinical Trial Activities–Findings From the Trials@Home RADIAL Proof-of-Concept Trial
First published: 1 October 2025
Authors: Katarzyna Lipinska, Danny van Weelij, Bart Lagerwaard, Linda Rutgrink, Eduard Vardianu, Petra Naster, Lina Pérez-Breva, Paul Bodfish, Megan Heath, Yvonne van Rijswick, Diederick E. Grobbee, Mira G.P. Zuidgeest, on behalf of the Trials@Home consortium
The Supply of Investigational Medicinal Product and Management of Study Materials for Decentralized Participants—Insights from the Trials@Home RADIAL Proof-of-Concept Trial
First published: 24 September 2025
Authors: Megan Heath, Amos J. de Jong, Shaun Magorrian-Spence, Chao Jin, Danny R. van Weelij, Lucas Pagnier, Yvonne van Rijswick, Volker Haufe, Bart Lagerwaard, Mira G. P. Zuidgeest, on behalf of the Trials@Home consortium
Operationalizing Decentralized Clinical Trials: Technology Insights from the Trials@Home RADIAL Proof-of-Concept Trial
First published: 19 September 2025
Authors: Sten Hanke, Dimitrios Giannikopoulos, Bernhard Neumayer, Tea Vedenkannas, Robert Davey, Lampros Mpaltadoros, Brian Guthrie, Rebecca Jackson, Bart Lagerwaard, Mira Zuidgeest, on behalf of the Trials@Home consortium
Recruiting and Consenting Decentralized Clinical Trial Participants—Learnings from the Trials@Home RADIAL Proof-of-Concept Trial
First published: 4 September 2025
Authors: Bart Lagerwaard, Linda Rutgrink, Danny van Weelij, Katarzyna Lipinska, Tina Bornemann, Robert Davey, Jaime Fons-Martinez, Sabine Dupont, Diederick E. Grobbee, Mira G. P. Zuidgeest, on behalf of the Trials@Home Consortium
Why and how do we perform physical examination(s) in clinical trials? A use case of drug intervention trials in type 2 diabetes mellitus
First published: 1 September 2025
Authors: Julia Kopanz, Amy Rogers, Lina Pérez-Breva, Emily Hall, Prashasthi Devaiah, Isla S. Mackenzie, Bart Lagerwaard, Diederick E. Grobbee, Mira G. P. Zuidgeest, on behalf of the Trials@Home consortium
Bringing Trial Activities to Participants—The Trials@Home RADIAL Proof-of-Concept Trial Investigating Decentralization of Trials
First published: 1 September 2025
Authors: Mira G.P. Zuidgeest, Megan Heath, Bart Lagerwaard, Danny R. van Weelij, Linda Rutgrink, Sten Hanke, Tea Vedenkannas, Taru Kosonen, Stefania Collamati, Jaime Fons-Martínez, Duco Veen, Helga Gardarsdottir, Isla S. Mackenzie, Sabine Dupont, Diederick E. Grobbee, on behalf of the Trials@Home consortium
Diversity in decentralized clinical trials: prioritizing inclusion of underrepresented groups
First published: 24 April 2025
Authors: Tessa I. van Rijssel, Johannes J. M. van Delden, Bart Lagerwaard, Mira G. P. Zuidgeest & Ghislaine J. M. W. van Thiel on behalf of the Trials@Home consortium
The impact of operational trial approaches on representativeness: Comparison of decentralized clinical trial participants, conventional trial participants, and patients in daily practice
First published: February 2025
Authors: Amos J. de Jong, Mira G.P. Zuidgeest, Yared Santa-Ana-Tellez, Christine E. Hallgreen, Thomas T. van Sloten, Anthonius de Boer, Helga Gardarsdottir, the Trials@Home Consortium
Why do Diabetic Participants Enroll in Clinical Trials?
First published: 28 January 2025
Authors: Julia Kopanz, Bart Lagerwaard, PhD, and Mira Zuidgeest, PhD
Regulatory readiness to facilitate the appropriate use of innovation in clinical trials: The case of decentralized clinical trial approaches
First published: November 2024
Authors: Amos J. de Jong, Mira G.P. Zuidgeest, Yared Santa-Ana-Tellez, Anthonius de Boer, Helga Gardarsdottir, the Trials@Home Consortium
The Digital Platform and Its Emerging Role in Decentralized Clinical Trials
First published: 3 September 2024
Authors: Rachel R Copland; Sten Hanke; Amy Rogers; Lampros Mpaltadoros; Ioulietta Lazarou; Alexandra Zeltsi; Spiros Nikolopoulos; Thomas M MacDonald; Isla S Mackenzie
The Ethics of Decentralized Clinical Trials and Informed Consent: Taking Technologies’ Soft Impacts into Account
First published: 30 April 2024
Authors: Tessa I. van Rijssel · Ghislaine J. M. W. van Thiel ·
Johannes J. M. van Delden · On behalf of the Trials@Home consortium
Technology Support System and Review Process for a Decentralized Clinical Trial: Trials@Home, RADIAL DCT as Case Study
First published: 21 February 2024
Authors: Sten Hanke, Dimitrios Giannikopoulos, Hannes Hilberger, Theresa Weitlaner and Bernhard Neumayer
Which Benefits Can Justify Risks in Research?
First published: 5 January 2024
Authors: Tessa I. van Rijssel, Ghislaine J. M. W. van Thiel, Helga Gardarsdottir, Johannes J. M. van Delden, on behalf of the Trials@Home consortium
Opportunities and challenges for decentralized clinical trial approaches: European health technology assessment perspective
First published: 1 December 2023
Authors: Amos J. de Jong, MSc, Nadi Shahid, BSc, Mira G.P. Zuidgeest, PhD, Yared Santa-Ana-Tellez, PhD, Milou Hogervorst, PharmD, Wim Goettsch, PhD, Hamidou Traore, PhD, Anthonius de Boer, PhD, Helga Gardarsdottir, PhD, on behalf of theTrials@Home Consortium
Direct-to-Participant Investigational Medicinal Product Supply in Clinical Trials in Europe – Exploring the Experiences of Sponsors, Site Staff, and Couriers
First published: 12 July 2023
Decentralised, patient-centric, site-less, virtual, and digital clinical trials? From confusion to consensus
First published: 6 February 2023
Green light for clinical research at patients’ homes?
Studies at patients’ homes may improve accessibility and inclusiveness of drug research
(white paper)
First published: 24 January 2023
A cross‑sectional survey on the early impact of COVID‑19 on the uptake of decentralised trial methods in the conduct of clinical trials
First published: 11 October 2022
Which decentralised trial activities are reported in clinical trial protocols of drug trials initiated in 2019–2020? A cross-sectional study in ClinicalTrials.gov
First published: 29 August 2022
A secondary qualitative analysis of stakeholder views about participant recruitment, retention, and adherence in decentralised clinical trials (DCTs)
First published: 30 July 2022
Ethics review of decentralized clinical trials (DCTs): Results of a mock ethics review
First published: 20 July 2022
Opportunities and Challenges for Decentralized Clinical Trials: European Regulators’ Perspective
First published: 30 April 2022
A Systematic Review of Methods used to Conduct Decentralised Clinical Trials
First published: 27 December 2021
An Overview of Technology Availability to Support Remote Decentralized Clinical Trials
First published: 28 September 2021
Learning from remote decentralised clinical trial experiences: A qualitative analysis of interviews with trial personnel, patient representatives and other stakeholders
First published: 13 July 2021
Authors: Joanne Coyle, Amy Rogers, Rachel Copland, Giorgia De Paoli, Thomas M. MacDonald, Isla S. Mackenzie, on behalf of the Trials@HomeConsortium